Xylo-comod nasal spray is used for temporary relief of congestion in the nose caused by various conditions including the common cold, sinusitis, hayfever and allergies. Xylo-comod nasal spray is a decongestant. Xylo-comod nasal spray works by narrowing the blood vessels in the nose area reducing swelling and congestion. Xylometazoline has vasoconstrictive properties, causing a mucous membrane swelling.